humane endpoint criteria define the conditions under which:

Humane endpoints function as an alternative to experimental endpoints … endobj more humane endpoints to animal experiments. Clinical and Translational Science Institute, Related Organizations: "���}�K�R��qOh�Lj7_;������皖yu#1�M��X�4�ZH�ܻ���ܫ ��M�9���mubXm��Y)��>��OPy�zx"��0s�%j�SI�0g_�T=A�x�>��(����艶���. Non-specific signs of illness such as inactivity, hunched posture or a rough coat are an indication that an animal should be examined more closely. These are different from experimental endpoints, which occur when scientific objectives have been met, but the two can be closely linked. �ʂT�0�f#�徺)wաl��&Y���\����f�Q��Z�����B#��7z�;T�b��ī�j�IW��:�7��; The Penn State Office of the Vice President for Research is committed to making its websites accessible to all users, and welcomes comments or suggestions on access improvements. In biomedical research using animal models, the phrase “humane endpoints” refers to predetermined criteria used to judge when the research animals should be humanely euthanized. Human rights are rights inherent to all human beings, regardless of race, sex, nationality, ethnicity, language, religion, or any other status. Quality Management Applied Research Laboratory Animal cruelty, like any other form of violence, is often committed by a person who feels powerless, unnoticed or under the control of others. Hershey-UP Shuttle Service �9����L_�, Familiarity with the animal model in use is necessary to select endpoints that are both humane and scientifically sound. Choose appropriate endpoints that are objective and relevant for the assessment of pain/distress in the species. i. Objective and easy to use for assessing the condition of animals used in research, especially studies where animals may experience some degree of debilitation as the study progresses. Dual Use Research of Concern Can be combined with Conditional Access, which can then block users and devices that don't meet the rules. Unmanned Air Systems Scientific Diving  x��][o�8�~�����Z�d�u�m4�Τ{z��p�̃\��T��K���_��B�N;��:��D��r.߹��|wj��b�?�p��m����&�|�Sݶ����������:mU.��[���n�ӏ? Criteria (human drugs) ... we can define a set of in vitro conditions that allows for the discrimination of inequivalent formulations. criteria will need to be well-defined and consistently applied, but it is recognized that these endpoints must be considered in assessing carcinogenic risk of any pharmaceutical. People with progressive conditions can be classed as disabled. What are the three conditions for continuity at a point? Institutional Review Board (IRB)  Simulating disease progression for a defined patient population can be used to evaluate, inform, and optimize clinical trial design, for example by projecting required sample sizes, iden… Consortium for Building Energy Innovation }z���gFq������@*R��� >���7���y���G931�L ��t^4�i(���|��}\~������ �n��� Innovation Park What is continuity at a point? 2.2 Definition of a Principal Surrogate Endpoint. Product Development Under the Animal Rule Guidance for Industry U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) The degree of weight loss should be specified in terms of % or quantity (grams, pounds, kg). Office of the President IT (OOPIT) Institutes of Energy and the Environment Regulated Biohazardous Materials (IBC) The motive may be to shock, threaten, intimidate or offend others or to demonstrate rejection of society's rules. determining humane endpoints for rodents used in tumor studies. Radioisotopes (UIC) Animals in this state are often comatose (unresponsive and unaware of stimuli) and so beyond awareness of suffering. Working conditions are at the core of paid work and employment relationships. Loss of ability to ambulate (inability to access food or water). Patentability Criteria: The Patents Act, 1970 does not defines what a patent is, instead it just says that a patent means a patent for any invention granted under the Act, which does not gives a clear picture about the meaning of the term Patent. Justification that no alternative can be used to accomplish the project objectives. Usually measured as mean diameter of the mass or tumor volume as a percentage of body weight (i.e. Actions for noncompliance can alert users to the conditions of noncompliance and safeguard data on noncompliant devices. INTRODUCTION The CCAC policy statement Ethics of Animal Investigation states: "Animals must not be subjected to unnecessary pain or distress. >����۪U�^�X�&a$]{ni����}M��c�b����刴��$M�t�ۿ�j�������_��m�;U��U}x��� D�Sw�P/�.�HT(f��Z��{�� �x�:_��D�|�u�r��ha���tU��թ�%��ɪ�57�'�/=���[b}�T>�'| ���4��Q������ %�>���M�]��"�N���]}���q�f.���n�����r��q�)�r�XW:��0JD������Pf3l���ل�7Ф��{`�}E����d�VH�,T.��B��q�s;�e�D&. The skin looses its elasticity. In a dehydrated animal the skin is slow to return to normal or remains tented. Materials Research Institute ?��}���7Q�\� 2 0 obj Please note, dehydration must be. 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